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Technology
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INNOVATIVE TECHNOLOGY
Conventional, or “on-pump” LVAD implantation requires use of
a cardiopulmonary bypass (CPB) machine, which, due to
bleeding and other risks,lead to one-month mortality rates
approaching 20%.[1]
Apaxis’s technology consists
of a surgical method and set of proprietary tools that allow
the surgeon to implant an LVAD on a beating heart. The
Apaxis
technology allows a lower-risk, off-pump LVAD implantation
that:
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Eliminates the need and
added cost of CPB and lowers surgical complications
Utilizes less-invasive surgical procedures and decreases
both OR time and average length of stay.
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Facilitating the
implantation of existing LVADs, thus expanding the
current market.
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Potential strategic
advantage to an existing LVAD maker to position against
emerging less-invasive delivery methods.
Click here to watch the
animated demonstration
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Technology Development and
Commercialization Status
Apaxis has successfully developed functional prototypes and completed
its proof of concept and is poised to complete FDA approval and
first in human trials.
Apaxis is developing a commercialization plan to seek equity
investments.
Apaxis's technology:
Apaxis’s technology
is delivered as a disposal surgical tool kit to facilitate
off-bypass LVAD implantation.
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EasyApex CV:
Suction-assisted heart positioner and sewing ring holder.
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Allows
the surgeon to position the sewing ring and to
facilitate attachment of the sewing ring to the left
ventricular apex without CPB.
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Endo LV: A specially
designed balloon catheter, threaded over a guide wire through
the femoral artery, across the aortic valve and the left
ventricular cavity.
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Provides temporary hemostatis after coring and excision
of ventricular tissue.
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ApiCor: Suction-assisted
coring tool.
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Advanced along the guide wire toward the apex of the
heart toward the left ventricle and the previously
attached sewing ring.
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The
ApiCor is designed with a spacer to prevent puncturing
of the Endo LV (balloon catheter).
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Anastomotic Suturing Connector:
A second-generation connector, yet to be designed, to obviate
the need for a sewing ring and suturing.
Apaxis’s tools are designed to be used with a commercially available
guide wire and endovascular snare wire.
Intellectual Property:
Apaxis has three formal patent applications pending.
1
Deng et al. J Heart Lung Transplant, 2005.
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